FP290 : Role of Mitomycin C As Adjunct Therapy for 3-Snip Punctoplasty in Correcting Punctal Stenosis

Dr. DeepakChoudhury, Dr. Jagdish Prasad Rout, Dr. PramodKumar Sharma, Dr. Kanhei Charan Tudu, Dr.Sharmistha Behera

PRESENTING AUTHOR:   Dr. Deepak Choudhury

CHIEF AUTHOR:      Dr. J P Rout

CO AUTHOR: Prof. Dr. J Dora, Dr. K C Tudu, Dr. S Behera, Dr. P K Sharma, Veer Surendra Sai Institute of Medical Science and Research, Burla, Odisha.

 FINANCIAL DISCLAIMER

The authors have no financial interest in any materials discussed in the presentation.

Introduction

  • Stenosis of lacrimal punctum has numerous causes, including infection with herpes simplex, herpes zoster, chlamydia, actinomyces & HPV.
  • It can be caused by rare systemic conditions such as porphyria cutanea tarda and acrodermatitis enteropathica, direct and thermal trauma or be secondary to topical or systemic chemotherapy & irradiation.
  • The surgery involved in attempting to resolve the stenosis is now commonly described as a 1-, 2-, or 3-snip procedure.
  • These descriptions imply the exact number of cuts required to perform the procedure

 Aim:-

  • To assess the efficacy of intraoperative mitomycin C in improving the success rate of the 3-snip punctoplasty procedure for punctual stenosis.

 Material & Methods :-

  • Prospective study of 36 eyes of 22 patients who underwent 3-snip punctoplasty in the Ophthalmology OT of a tertiary health care centre in western Odisha.

– Study design:- Prospective study

-Study period:- 13 months  (April 2014 to April 2015)

 Methods:-

  • Detailed history taking
  • Examination
  • Laboratory investigations
  • 1ml of 2% lignocaine with 1 : 10 0000 epinephrine injected subcutaneously below lower punctum.
  • Punctum dilated sufficiently to allow the posterior wall of ampulla to be grasped with toothed microforceps.
  • Vannas scissors used to excise posterior wall of the ampulla with three snips, the first two downwards on each side of the forceps and the third across the bottom.
  • The procedure was done without mitomycin C in 14 eyes and with mitomycin C 0.01% intraoperatively for 2 min in 22 eyes under local anaesthesia.

 Results:-

  • 36 eyes of 22 patients underwent 3-snip punctoplasty.
  • Age range was from 16 to 63 years
  • 2 % patients were female
  • In group without mitomycin c, 4 of 14 (28.6%) eyes had complete anatomic obstruction and scarring of their puncta after surgery
  • All 22 eyes in group with mitomycin c had patent puncta and there was no scarring following surgery.
  • The difference was statistically significant (P=0.03).
  • No significant complications were observed after surgery.

Fig- 1:- 3 snip punctoplasty

Discussion:-

  • Ceasar et al found in a study the age range was from 9 to 89 years with a mean of 56 years. A total of 74% of patients were female. The success rate following 3 snip punctoplasty was 92%.1
  • According to Maluf et al Mitomycin C appears to be a safe and effective adjunct therapy in correcting punctal stenosis

Conclusion:-

  • Mitomycin C appears to be a safe and effective adjunct therapy in correcting punctal stenosis.

References:-

  • Caesar H, McNab A. A brief history of punctoplasty: the 3-snip revisited. Eye. 2005; 19: 16-8.
  • Maluf R, Hamus N, Awwad S. Mitomycin C as adjunct therapy in correcting punctal stenosis. Ophthal Plast Reconstr Surg.2002 Jul;18(4):285-8.

 

 

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