Dr. Gurunadh Satyanarayana Velamakanni, G03477, Dr. (Wing Cdr) Mansur Ali Khan, Dr. Sandeep, Dr. (Brig) Parthasarathi Moulick
Elevated level of serum ceruloplasmin is a biomarker for oxidative stress. Diabetes is a state of oxidative stress. There is paucity of literature regarding elevation of serum levels of ceruloplasmin in type 2 diabetics with diabetic retinopathy (DR). Forty two diagnosed type 2 diabetics with DR and equal age and sex matched diabetics without DR were evaluated. Serum ceruloplasmin levels were evaluated by Ambade method in all these patients. The normal levels of serum ceruloplasmin at the lab were taken as 787+128 IU/L.The mean ceruloplasmin level in all 84 patients was 1192.66 +/- 271.62 IU/L which was statistically significantly higher than the normal values indicating that levels of ceruloplasmin are raised in diabetics confirming the presence of significant oxidative stress. Mean ceruloplasmin levels in DR group was 1227.07±275.70 IU/L which was higher than levels of 1158.26±267.54 IU/L in patients without DR indicating that DR enhances the oxidative stres