Dr. Tarannum Mansoori, M07554, Dr. Satish G Agraharam
Purpose : To propose a novel method for capillary density measurement from optical coherence tomography angiography (OCTA) images for glaucoma assessment
Methods : The methodology comprises of three stages i.e. extraction of region of interest (ROI) around optic nerve head, detection of thick vessels and determination of capillary density (CD) from OCTA images. The proposed method was then validated against data obtained from 49 normal eyes and 22 glaucoma patients.
Results: Quantitative estimation of the method was done by comparing sensitivity, specificity and accuracy .Capillary density measurement had better sensitivity to detect glaucoma when compared to retinal nerve fiber layer thickness (RNFLT).
Conclusion: A combination of vascular dysfunction (CD) and structural loss (RNFLT) has best sensitivity for detection of glaucoma. Results from our study using a new method to measure CD are promising and encourage further evaluation on a larger dataset of glaucoma patients.