Dr. Paaraj Dave,D13919
Purpose:To compare the in-vitro bacterial kill rate of branded and generic moxifloxacin eye drops.
Methods:An observational study done in a laboratory setting. Bacterial culture of Staphylococcus aureus was used in the study. Commercial formulations of 1 branded (Vigamox) and 3 generic (Moxoft, Milflox, Moxicip) 0.5% moxifloxacin drops were used. Bacterial culture was inoculated in Mueller-Hinton Broth and incubated for 4 hours at 37˚C. After incubation, the optical density was adjusted to obtain the McFarland standard. A 0.5 ml volume of culture was inoculated in 0.5 ml of 1:100 dilution of moxifloxacin 0.5 % drops. Aliquots of 0.1 ml were plated at 0, 15, 30 and 60 minutes on Mueller-Hinton agar plates and incubated at 37˚C. Bacterial colony counts were noted after 24 hours.
Results:Moxicip had the lowest bacterial colony count at all time points.
Conclusion:All generic medications are not alike and physician experience & discretion can result in cost effective treatment approach.