Prabha Gupta, Dr. Deepa John, Dr. Sheeja John
OBJECTIVES
To determine the association of hyperhomocysteinemia with proliferative diabetic retinopathy
METHODS
Design: Hospitalbased, case control study.
Serum homocysteine levels were estimated in 39 Type 2 diabetics with proliferative diabetic
retinopathy (PDR cases), and 39 controls (age and gender matched) with no retinopathy (No DR). Data were documented and analyzed.
RESULTS
The prevalence of hyperhomocysteinemia was higher in cases with PDR compared to controls with No DR (59% vs. 48.7%); however this difference was not statistically significant (p = 0.36). The difference between the mean serum homocysteine levels in cases and controls was not statistically significant (17.98 + 6.26 μmol/L vs. 17.71 + 8.17 μmol/L; p = 0.87).
CONCLUSION
There was no statistically significant difference in either the prevalence of hyperhomocysteinemia or the mean serum homocysteine levels between the cases with PDR and the controls with no DR.