FP1363 : Ophthalmic Manifestations of Wegener’s GranulomatosisDr. Raksha Rao (R17558)
Purpose: To describe various ophthalmic manifestations of Wegener’s granulomatosis (WG).
Methods: Retrospective chart review.
Results: Four patients with 4 different presentations were diagnosed with WG at a mean age of 17 years. 1 patient had necrotising scleritis, 1 severe proptosis, 1 an orbital mass, and 1 bilateral chronic dacryocystitis. All patients had biopsy-proven necrotising granulomatous inflammation, with p-ANCA positive in 3 patients. One patient also had systemic manifestations of the disease. All underwent treatment with systemic steroids, with or without immunomodulatory agents. The patient with scleritis was treated with Rituximab, and the patient with proptosis received radiotherapy for disease control.
Conclusion: Ophthalmic WG is a clinicopathologic diagnosis, with a constellation of ocular manifestations. The emergence of new treatment regimens such as rituximab is bringing promise in providing patients with better and potentially safer treatment for the disease
